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Maximum-likelihood joint image reconstruction and motion estimation with misaligned attenuation in TOF-PET/CT.

Bousse, A; Bertolli, O; Atkinson, D; Arridge, S; Ourselin, S; Hutton, BF; Thielemans, K; (2016) Maximum-likelihood joint image reconstruction and motion estimation with misaligned attenuation in TOF-PET/CT. Physics in Medicine and Biology , 61 (3) L11-L19. 10.1088/0031-9155/61/3/L11. Green open access

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Abstract

This work is an extension of our recent work on joint activity reconstruction/motion estimation (JRM) from positron emission tomography (PET) data. We performed JRM by maximization of the penalized log-likelihood in which the probabilistic model assumes that the same motion field affects both the activity distribution and the attenuation map. Our previous results showed that JRM can successfully reconstruct the activity distribution when the attenuation map is misaligned with the PET data, but converges slowly due to the significant cross-talk in the likelihood. In this paper, we utilize time-of-flight PET for JRM and demonstrate that the convergence speed is significantly improved compared to JRM with conventional PET data.

Type: Article
Title: Maximum-likelihood joint image reconstruction and motion estimation with misaligned attenuation in TOF-PET/CT.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1088/0031-9155/61/3/L11
Publisher version: http://dx.doi.org/10.1088/0031-9155/61/3/L11
Language: English
Additional information: Original content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence (CC-BY). Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Metabolism and Experi Therapeutics
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1477091
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