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The development, evaluation and performance of molecular diagnostics for detection of Mycobacterium tuberculosis.

Bates, M; Zumla, A; (2016) The development, evaluation and performance of molecular diagnostics for detection of Mycobacterium tuberculosis. Expert Review of Molecular Diagnostics , 16 (3) pp. 307-322. 10.1586/14737159.2016.1139457.

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Abstract

The unique pathogenesis of tuberculosis (TB) poses several barriers to the development of accurate diagnostics: a) the establishment of life-long latency by Mycobacterium tuberculosis (M.tb) after primary infection confounds the development of classical antibody or antigen based assays; b) our poor understanding of the molecular pathways that influence progression from latent to active disease; c) the intracellular nature of M.tb infection in tissues means that M.tb and/or its components, are not readily detectable in peripheral specimens; and d) the variable presence of M.tb bacilli in specimens from patients with extrapulmonary TB or children. The literature on the current portfolio of molecular diagnostics tests for TB is reviewed here and the developmental pipeline is summarized. Also reviewed are data from recently published operational research on the GeneXpert MTB/RIF assay and discussed are the lessons that can be taken forward for the design of studies to evaluate the impact of TB diagnostics.

Type: Article
Title: The development, evaluation and performance of molecular diagnostics for detection of Mycobacterium tuberculosis.
Location: England
DOI: 10.1586/14737159.2016.1139457
Publisher version: http://dx.doi.org/10.1586/14737159.2016.1139457
Language: English
Additional information: This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Review of Molecular Diagnostics on 17/02/2016, available online: http://dx.doi.org/10.1586/14737159.2016.1139457.
Keywords: FIND, Molecular Diagnostics, Tuberculosis, WHO, Xpert, biomarker, smear microscopy
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/1477054
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