Watanabe, T;
Hanajima, R;
Shirota, Y;
Tsutsumi, R;
Shimizu, T;
Hayashi, T;
Terao, Y;
... Konishi, S; + view all
(2015)
Effects of rTMS of pre-supplementary motor area on fronto basal ganglia network activity during stop-signal task.
Journal of Neuroscience
, 35
(12)
pp. 4813-4823.
10.1523/JNEUROSCI.3761-14.2015.
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Abstract
Stop-signal task (SST) has been a key paradigm for probing human brain mechanisms underlying response inhibition, and the inhibition observed in SST is now considered to largely depend on a fronto basal ganglia network consisting mainly of right inferior frontal cortex, pre-supplementary motor area (pre-SMA), and basal ganglia, including subthalamic nucleus, striatum (STR), and globus pallidus pars interna (GPi). However, causal relationships between these frontal regions and basal ganglia are not fully understood in humans. Here, we partly examined these causal links by measuring human fMRI activity during SST before and after excitatory/inhibitory repetitive transcranial magnetic stimulation (rTMS) of pre-SMA. We first confirmed that the behavioral performance of SST was improved by excitatory rTMS and impaired by inhibitory rTMS. Afterward, we found that these behavioral changes were well predicted by rTMS-induced modulation of brain activity in pre-SMA, STR, and GPi during SST. Moreover, by examining the effects of the rTMS on resting-state functional connectivity between these three regions, we showed that the magnetic stimulation of pre-SMA significantly affected intrinsic connectivity between pre-SMA and STR, and between STR and GPi. Furthermore, the magnitudes of changes in resting-state connectivity were also correlated with the behavioral changes seen in SST. These results suggest a causal relationship between pre-SMA and GPi via STR during response inhibition, and add direct evidence that the fronto basal ganglia network for response inhibition consists of multiple top-down regulation pathways in humans.
| Type: | Article |
|---|---|
| Title: | Effects of rTMS of pre-supplementary motor area on fronto basal ganglia network activity during stop-signal task |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1523/JNEUROSCI.3761-14.2015 |
| Publisher version: | http://dx.doi.org/10.1523/JNEUROSCI.3761-14.2015 |
| Language: | English |
| Additional information: | Copyright © The Authors 2015. This article has become available, six months following publication, under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | QPS, partial correlation, response cancellation, response inhibition, Adult, Basal Ganglia, Brain Mapping, Frontal Lobe, Humans, Inhibition (Psychology), Magnetic Resonance Imaging, Male, Motor Cortex, Neural Pathways, Psychomotor Performance, Transcranial Magnetic Stimulation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1476940 |
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