Castelletto, V;
De Santis, E;
Alkassem, H;
Lamarre, B;
Noble, JE;
Ray, S;
Bella, A;
... Ryadnov, MG; + view all
(2016)
Structurally plastic peptide capsules for synthetic antimicrobial viruses.
Chemical Science
, 7
(3)
pp. 1707-1711.
10.1039/c5sc03260a.
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Abstract
A conceptual design for artificial antimicrobial viruses is described. The design emulates viral assembly and function to create self-assembling peptide capsules that promote efficient gene delivery and silencing in mammalian cells. Unlike viruses, however, the capsules are antimicrobial, which allows them to exhibit a dual biological function: gene transport and antimicrobial activity. Unlike other antimicrobials, the capsules act as pre-concentrated antimicrobial agents that elicit rapid and localised membrane-disrupting responses by converting into individual pores at their precise landing positions on membranes. The concept holds promise for engineering virus-like scaffolds with biologically tuneable properties.
| Type: | Article |
|---|---|
| Title: | Structurally plastic peptide capsules for synthetic antimicrobial viruses |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c5sc03260a |
| Publisher version: | http://dx.doi.org/10.1039/c5sc03260a |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence (http://creativecommons.org/licenses/by-nc/3.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Physics and Astronomy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1476738 |
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