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Structurally plastic peptide capsules for synthetic antimicrobial viruses

Castelletto, V; De Santis, E; Alkassem, H; Lamarre, B; Noble, JE; Ray, S; Bella, A; ... Ryadnov, MG; + view all (2016) Structurally plastic peptide capsules for synthetic antimicrobial viruses. Chemical Science , 7 (3) pp. 1707-1711. 10.1039/c5sc03260a. Green open access

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Abstract

A conceptual design for artificial antimicrobial viruses is described. The design emulates viral assembly and function to create self-assembling peptide capsules that promote efficient gene delivery and silencing in mammalian cells. Unlike viruses, however, the capsules are antimicrobial, which allows them to exhibit a dual biological function: gene transport and antimicrobial activity. Unlike other antimicrobials, the capsules act as pre-concentrated antimicrobial agents that elicit rapid and localised membrane-disrupting responses by converting into individual pores at their precise landing positions on membranes. The concept holds promise for engineering virus-like scaffolds with biologically tuneable properties.

Type: Article
Title: Structurally plastic peptide capsules for synthetic antimicrobial viruses
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c5sc03260a
Publisher version: http://dx.doi.org/10.1039/c5sc03260a
Language: English
Additional information: This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence (http://creativecommons.org/licenses/by-nc/3.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Physics and Astronomy
URI: https://discovery.ucl.ac.uk/id/eprint/1476738
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