Li, X;
Tse, VC;
Wai, ADL;
Chan, EW;
Wong, ICK;
(2016)
The impact of ischemic stroke on atrial fibrillation-related healthcare cost: a systematic review.
Europace
, 19
(6)
pp. 937-947.
10.1093/europace/euw093.
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Abstract
Aim: To summarize healthcare costs incurred by patients with atrial fibrillation (AF) who developed ischemic stroke, explore factors associated with increased cost and highlight the importance of anticoagulation therapy for stroke prophylaxis. / Methods: A systematic literature search of PubMed, EMBASE, Web of Science and the health economic evaluation database was conducted up to December 2015. Studies focused on the cost and/or resource utilization of ischemic stroke in patients with AF were included. Reported costs were converted to international dollars (I$) and adjusted to 2015 values. Alongside the narrative review of included studies, Spearman’s correlation, independent-samples t-test and one-way ANOVA were used to explore factors associated with cost differences between studies. / Results: Sixteen studies published from nine countries were identified. Based on currency conversion rates in 2015, ischemic stroke related healthcare costs were estimated to be I$41,420, I$12,895 and I$8,184 for high-income, upper middle-income and lower middle-income economies respectively. Local GDP per capita accounted for approximately 50% of the healthcare cost variation among countries. Major component of overall cost was from hospitalization. Ischemic stroke incurring in patients with AF ≥75 years were 2.3 times that of their younger peers (p=0.049). / Conclusions: The economic burden from ischemic stroke in patients with AF is considerable with positive association to country income. Clinicians and stakeholders should be aware of the importance of anticoagulation therapies in stroke prophylaxis, the occurrence of stroke and the downstream economic burden on an increasingly aging population.
| Type: | Article |
|---|---|
| Title: | The impact of ischemic stroke on atrial fibrillation-related healthcare cost: a systematic review |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/europace/euw093 |
| Publisher version: | http://dx.doi.org/10.1093/europace/euw093 |
| Language: | English |
| Additional information: | This is a pre-copyedited, author-produced PDF of an article accepted for publication in Europace following peer review. The version of record, Li, X; Tse, VC; Wai, ADL; Chan, EW; Wong, ICK; (2016) The impact of ischemic stroke on atrial fibrillation-related healthcare cost: a systematic review. Europace, is available online at: http://dx.doi.org/10.1093/europace/euw093 |
| Keywords: | stroke prophylaxis, atrial fibrillation, anticoagulation therapy, healthcare cost |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Practice and Policy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1476728 |
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