UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

T2 relaxometry in the extremely-preterm brain at adolescence

Dingwall, N; Chalk, A; Martin, TI; Scott, CJ; Semedo, C; Le, Q; Orasanu, E; ... Ourselin, S; + view all (2016) T2 relaxometry in the extremely-preterm brain at adolescence. Magnetic Resonance Imaging , 34 (4) pp. 508-514. 10.1016/j.mri.2015.12.020. Green open access

[thumbnail of 1-s2.0-S0730725X1500315X-main.pdf]
Preview
Text
1-s2.0-S0730725X1500315X-main.pdf - Published Version

Download (1MB) | Preview

Abstract

Survival following very preterm birth is associated with cognitive and behavioural sequelae, which may have identifiable neural correlates. Many survivors of modern neonatal care in the 1990s are now young adults and the evolution of MRI findings into adult life has rarely been evaluated. We have investigated a cohort of 19-year-old adolescents without severe impairments born between 22 and 26 weeks of gestation in 1995 (extremely preterm: EP). Using T2 data derived from Magnetic Resonance Imaging we investigate differences between the brains of 46 EP participants (n=46) and the brains of a group of term-born controls (n=20). Despite EP adolescents having significantly reduced grey and white matter volumes, the composition of these tissues, assessed by both single and multi- component relaxometry, appears to be unrelated to either preterm status or gender. This may represent either insensitivity of the imaging technique or reflect that there are only subtle differences between EP subjects and their term-born peers.

Type: Article
Title: T2 relaxometry in the extremely-preterm brain at adolescence
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.mri.2015.12.020
Publisher version: http://dx.doi.org/10.1016/j.mri.2015.12.020
Language: English
Additional information: © 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Prematurity, T2 relaxometry, myelin
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Neonatology
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1476641
Downloads since deposit
157Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item