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Innate and adaptive immunity in the development of depression: An update on current knowledge and technological advances

Haapakoski, R; Ebmeier, KP; Alenius, H; Kivimäki, M; (2016) Innate and adaptive immunity in the development of depression: An update on current knowledge and technological advances. Progress in Neuro-Psychopharmacology and Biological Psychiatry , 66 pp. 63-72. 10.1016/j.pnpbp.2015.11.012. Green open access

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Abstract

The inflammation theory of depression, proposed over 20years ago, was influenced by early studies on T cell responses and since then has been a stimulus for numerous research projects aimed at understanding the relationship between immune function and depression. Observational studies have shown that indicators of immunity, especially C reactive protein and proinflammatory cytokines, such as interleukin 6, are associated with an increased risk of depressive disorders, although the evidence from randomized trials remains limited and only few studies have assessed the interplay between innate and adaptive immunity in depression. In this paper, we review current knowledge on the interactions between central and peripheral innate and adaptive immune molecules and the potential role of immune-related activation of microglia, inflammasomes and indoleamine-2,3-dioxygenase in the development of depressive symptoms. We highlight how combining basic immune methods with more advanced 'omics' technologies would help us to make progress in unravelling the complex associations between altered immune function and depressive disorders, in the identification of depression-specific biomarkers and in developing immunotherapeutic treatment strategies that take individual variability into account.

Type: Article
Title: Innate and adaptive immunity in the development of depression: An update on current knowledge and technological advances
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.pnpbp.2015.11.012
Publisher version: http://dx.doi.org/10.1016/j.pnpbp.2015.11.012
Language: English
Additional information: © 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Adaptive immunity, Cytokine, Depression, Inflammation, Innate immunity, Omics technologies
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: https://discovery.ucl.ac.uk/id/eprint/1476627
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