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Resilience and MRI correlates of cognitive impairment in community-dwelling elders

Topiwala, A; Allan, CL; Valkanova, V; Zsoldos, E; Filippini, N; Sexton, CE; Mahmood, A; ... Ebmeier, KP; + view all (2015) Resilience and MRI correlates of cognitive impairment in community-dwelling elders. British Journal of Psychiatry , 207 (5) pp. 435-439. 10.1192/bjp.bp.114.152363. Green open access

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Abstract

BACKGROUND: The contribution of education and intelligence to resilience against age-related cognitive decline is not clear, particularly in the presence of 'normal for age' minor brain abnormalities. METHOD: Participants (n = 208, mean age 69.2 years, s.d. = 5.4) in the Whitehall II imaging substudy attended for neuropsychological testing and multisequence 3T brain magnetic resonance imaging. Images were independently rated by three trained clinicians for global and hippocampal atrophy, periventricular and deep white matter changes. RESULTS: Although none of the participants qualified for a clinical diagnosis of dementia, a screen for cognitive impairment (Montreal Cognitive Assessment (MoCA) <26) was abnormal in 22%. Hippocampal atrophy, in contrast to other brain measures, was associated with a reduced MoCA score even after controlling for age, gender, socioeconomic status, years of education and premorbid IQ. Premorbid IQ and socioeconomic status were associated with resilience in the presence of hippocampal atrophy. CONCLUSIONS: Independent contributions from a priori risk (age, hippocampal atrophy) and resilience (premorbid function, socioeconomic status) combine to predict measured cognitive impairment.

Type: Article
Title: Resilience and MRI correlates of cognitive impairment in community-dwelling elders
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1192/bjp.bp.114.152363
Publisher version: http://dx.doi.org/10.1192/bjp.bp.114.152363
Additional information: © The Royal College of Psychiatrists 2015. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) licence
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: https://discovery.ucl.ac.uk/id/eprint/1476537
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