UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Directing cell therapy to anatomic target sites in vivo with magnetic resonance targeting

Muthana, M; Kennerley, AJ; Hughes, R; Fagnano, E; Richardson, J; Paul, M; Murdoch, C; ... Lewis, C; + view all (2015) Directing cell therapy to anatomic target sites in vivo with magnetic resonance targeting. Nature Communications , 6 , Article 8009. 10.1038/ncomms9009. Green open access

[thumbnail of Directing cell therapy to anatomic target sites in vivo with magnetic resonance targeting.pdf]
Preview
Text
Directing cell therapy to anatomic target sites in vivo with magnetic resonance targeting.pdf - Published Version

Download (3MB) | Preview

Abstract

Cell-based therapy exploits modified human cells to treat diseases but its targeted application in specific tissues, particularly those lying deep in the body where direct injection is not possible, has been problematic. Here we use a magnetic resonance imaging (MRI) system to direct macrophages carrying an oncolytic virus, Seprehvir, into primary and metastatic tumour sites in mice. To achieve this, we magnetically label macrophages with super-paramagnetic iron oxide nanoparticles and apply pulsed magnetic field gradients in the direction of the tumour sites. Magnetic resonance targeting guides macrophages from the bloodstream into tumours, resulting in increased tumour macrophage infiltration and reduction in tumour burden and metastasis. Our study indicates that clinical MRI scanners can not only track the location of magnetically labelled cells but also have the potential to steer them into one or more target tissues.

Type: Article
Title: Directing cell therapy to anatomic target sites in vivo with magnetic resonance targeting
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/ncomms9009
Publisher version: http://dx.doi.org/10.1038/ncomms9009
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1476509
Downloads since deposit
229Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item