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An excitatory basis for divisive normalization in visual cortex

Sato, TK; Haider, B; Häusser, M; Carandini, M; (2016) An excitatory basis for divisive normalization in visual cortex. Nature Neuroscience , 19 (4) pp. 568-570. 10.1038/nn.4249. Green open access

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Abstract

Neurons in visual cortex are connected not only locally, but also through networks of distal connectivity. These distal networks recruit both excitatory and inhibitory synapses and result in divisive normalization. Normalization is traditionally thought to result from increases in synaptic inhibition. By combining optogenetic stimulation and intracellular recordings in mouse visual cortex, we found that, on the contrary, normalization is a result of a decrease in synaptic excitation.

Type: Article
Title: An excitatory basis for divisive normalization in visual cortex
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/nn.4249
Publisher version: http://dx.doi.org/10.1038/nn.4249
Language: English
Additional information: Copyright © 2016 Macmillan Publishers Limited. All Rights Reserved.
Keywords: Neural circuits, striate cortex
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/1476422
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