Kalafateli, M;
Mantzoukis, K;
Choi Yau, Y;
Mohammad, AO;
Arora, S;
Rodrigues, S;
de Vos, M;
... Tsochatzis, EA; + view all
(2017)
Malnutrition and sarcopenia predict post-liver transplantation outcomes independently of the Model for End-stage Liver Disease score.
Journal of Cachexia, Sarcopenia and Muscle
, 8
(1)
pp. 113-121.
10.1002/jcsm.12095.
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Abstract
Background: Although malnutrition and sarcopenia are prevalent in cirrhosis, their impact on outcomes following liver transplantation is not well documented. Methods: The associations of nutritional status and sarcopenia with post-transplant infections, requirement for mechanical ventilation, intensive care (ICU) and hospital stay, and 1year mortality were assessed in 232 consecutive transplant recipients. Nutritional status and sarcopenia were assessed using the Royal Free Hospital-Global Assessment (RFH-GA) tool and the L3-psoas muscle index (L3-PMI) on CT, respectively. Results: A wide range of RFH-SGA and L3-PMI were observed within similar Model for End-stage Liver Disease (MELD) sub-categories. Malnutrition and sarcopenia were independent predictors of all outcomes. Post-transplant infections were associated with MELD (OR=1.055, 95%CI=1.002-1.11) and severe malnutrition (OR=6.55, 95%CI=1.99-21.5); ventilation>24h with MELD (OR=1.1, 95%CI=1.036-1.168), severe malnutrition (OR=8.5, 95%CI=1.48-48.87) and suboptimal donor liver (OR=2.326, 95%CI=1.056-5.12); ICU stay>5days, with age (OR=1.054, 95%CI=1.004-1.106), MELD (OR=1.137, 95%CI=1.057-1.223) and severe malnutrition (OR=7.46, 95%CI=1.57-35.43); hospital stay>20days with male sex (OR=2.107, 95%CI=1.004-4.419) and L3-PMI (OR=0.996, 95%CI=0.994-0.999); 1year mortality with L3-PMI (OR=0.996, 95%CI=0.992-0.999). Patients at the lowest L3-PMI receiving suboptimal grafts had longer ICU/hospital stay and higher incidence of infections. Conclusions: Malnutrition and sarcopenia are associated with early post-liver transplant morbidity/mortality. Allocation indices do not include nutritional status and may jeopardize outcomes in nutritionally compromised individuals.
| Type: | Article |
|---|---|
| Title: | Malnutrition and sarcopenia predict post-liver transplantation outcomes independently of the Model for End-stage Liver Disease score |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/jcsm.12095 |
| Publisher version: | http://dx.doi.org/10.1002/jcsm.12095 |
| Language: | English |
| Additional information: | Copyright © 2016 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society of Sarcopenia, Cachexia and Wasting Disorders. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
| Keywords: | Cirrhosis; Prognosis; Nutritional assessment; Morbidity; Mortality |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1476377 |
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