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Factors influencing the outcome of intrauterine insemination (IUI): age, clinical variables and significant thresholds

Speyer, B; Abramov, B; Saab, W; Doshi, A; Sarna, U; Harper, JC; Serhal, P; (2013) Factors influencing the outcome of intrauterine insemination (IUI): age, clinical variables and significant thresholds. Journal of Obstetrics and Gynaecology , 33 (7) pp. 697-700. 10.3109/01443615.2013.810199. Green open access

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Abstract

The aim was to investigate the influence of various biological factors upon the outcome of intrauterine insemination (IUI). The total IUI history (856 cycles) of 352 couples was studied. Live-birth showed a strong negative correlation with female age but no correlation with male age. Antimullerian hormone (AMH) and antral follicle count (AFC) correlated negatively with female age, and follicle stimulating hormone (FSH) correlated positively. Significant thresholds were found for all three variables, and also for total motile count (TMC) in the prepared sperm. Calculating pregnancy losses per positive pregnancy showed a strong correlation with increasing female age. This was highly significant for biochemical losses but not for fetal heart miscarriages. Male age had no effect on rate of pregnancy loss. In conclusion, female age, FSH, AMH and TMC are good predictive factors for live-birth and therefore relate to essential in vivo steps in the reproductive process.

Type: Article
Title: Factors influencing the outcome of intrauterine insemination (IUI): age, clinical variables and significant thresholds
Open access status: An open access version is available from UCL Discovery
DOI: 10.3109/01443615.2013.810199
Publisher version: http://dx.doi.org/10.3109/01443615.2013.810199
Language: English
Additional information: This is an Accepted Manuscript of an article published by Taylor & Francis in Journal of Obsterics and Gynaecology on 15 October 2013, available online: http://www.tandfonline.com/10.3109/01443615.2013.817976
Keywords: Antimüllerian hormone, female age, FSH, intrauterine insemination, pregnancy loss, total motile count
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Reproductive Health
URI: https://discovery.ucl.ac.uk/id/eprint/1476297
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