O'Keeffe, AG;
Nazareth, I;
Petersen, I;
(2016)
Time trends in the prescription of statins for the primary prevention of cardiovascular disease in the United Kingdom: A cohort study using The Health Improvement Network (THIN) primary care data.
Clinical Epidemiology
, 8
pp. 123-132.
10.2147/CLEP.S104258.
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Abstract
BACKGROUND: Statins are widely prescribed for the primary prevention of cardiovascular disease. Guidelines exist for statin prescriptions but there is little recent analysis concerning prescription trends over time and how these vary with respect to demographic variables. / METHODS AND RESULTS: Using the THIN primary care database, statin therapy initiation and statin prescription prevalence rates were calculated using data from 7,027,711 individuals across the UK for the years 1995 to 2013, overall and stratified by gender, age group and socio-economic deprivation level (Townsend score). Statin therapy initiation rates rose sharply from 1995 (0.51 per 1000 personyears) up to 2006 (19.83 per 1000 person-years) and thereafter declined (10.76 per 1000 personyears in 2013). Males had higher initiation rates than females and individuals aged 60-85 years had higher initiation rates than younger or more elderly age groups. Initiation rates were slightly higher as social deprivation level increased, after accounting for age and gender. Prescription prevalence increased sharply from 1995 (2.36 per 1000 person-years) to 2013 (128.03 per 1000 person-years) with males generally having a higher prevalence rate, over time, than females. Prevalence rates over time were generally higher for older age groups but were similar with respect to social deprivation level. / CONCLUSIONS: The uptake of statins within UK primary care has increased greatly over time with statins being more commonly prescribed to older patients in general and, in recent years, males appear to have been prescribed statins at higher rates than females. After accounting for age and gender, the statin therapy initiation rate increases with the level of social deprivation.
| Type: | Article |
|---|---|
| Title: | Time trends in the prescription of statins for the primary prevention of cardiovascular disease in the United Kingdom: A cohort study using The Health Improvement Network (THIN) primary care data |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.2147/CLEP.S104258 |
| Publisher version: | https://dx.doi.org/10.2147/CLEP.S104258 |
| Language: | English |
| Additional information: | This work is published by Dove Medical Press Limited, and licensed under a Creative Commons Attribution License. The full terms of the License are available at http://creativecommons.org/licenses/by/4.0/. The license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Keywords: | Cardiovascular disease, Primary prevention, Statin therapy, Time trend, United Kingdom |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Primary Care and Population Health UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Statistical Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1475952 |
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