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Osteoblast response to zirconia surfaces with different topographies

Herath, HM; Di Silvio, L; Evans, JR; (2015) Osteoblast response to zirconia surfaces with different topographies. Materials Science and Engineering: C , 57 pp. 363-370. 10.1016/j.msec.2015.07.052. Green open access

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Abstract

Zirconia-3 mol% yttria ceramics were prepared with as-sintered, abraded, polished, and porous surfaces in order to explore the attachment, proliferation and differentiation of osteoblast-like cells. After modification, all surfaces were heated to 600°C to extinguish traces of organic contamination. All surfaces supported cell attachment, proliferation and differentiation but the surfaces with grain boundary grooves or abraded grooves provided conditions for enhanced initial cell attachment. Nevertheless, overall cell proliferation and total DNA were highest on the polished surface. Zirconia sintered at a lower temperature (1300°C vs. 1450°C) had open porosity and presented reduced proliferation as assessed by alamarBlue™ assay, possibly because the openness of the pores prevented cells developing a local microenvironment. All cells retained the typical polygonal morphology of osteoblast-like cells with variations attributable to the underlying surface notably alignment along the grooves of the abraded surface.

Type: Article
Title: Osteoblast response to zirconia surfaces with different topographies
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.msec.2015.07.052
Publisher version: http://dx.doi.org/10.1016/j.msec.2015.07.052
Language: English
Additional information: Copyright © 2015. This manuscript version is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International licence (CC BY-NC-ND 4.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licences are available at http://creativecommons.org/licenses/by/4.0.
Keywords: Biocompatibility, Cell culture, Osteoblast, Topography, Zirconia
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/1475779
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