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Multi atlas-based attenuation correction for brain FDG-PET imaging using a TOF-PET/MR scanner- comparison with clinical single atlas- and CT-based attenuation correction

Sekine, T; Burgos, N; Warnock, G; Huellner, MW; Buck, A; Ter Voert, EE; Cardoso, MJ; ... Delso, G; + view all (2016) Multi atlas-based attenuation correction for brain FDG-PET imaging using a TOF-PET/MR scanner- comparison with clinical single atlas- and CT-based attenuation correction. Journal of Nuclear Medicine , 57 (8) pp. 1258-1264. 10.2967/jnumed.115.169045. Green open access

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Abstract

To assess the feasibility of attenuation correction (AC) based on a multi atlas-based method (m-Atlas) by comparing it with a clinical AC method (single atlas-based method (s-Atlas)), on a time of flight (TOF)-PET/MRI system. METHODS: We enrolled 12 patients. The median patient age was 62 years [range 31 to 80]. All patients underwent a clinically indicated whole-body(18)F-FDG-PET/CT (GE Healthcare Discovery 690 PET/CT) for staging, re-staging or follow-up of malignant disease. All patients volunteered for an additional PET/MR scan of the head (GE Healthcare SIGNA PET/MR) (no additional tracer being injected). For each patient, 3 AC maps were generated. Both s-Atlas and m-Atlas AC maps were generated from the same patient-specific LAVA-FLEX T1-weighted (T1w) images, being acquired by default on the PET/MR scanner during the first 18s of the PET scan. S-Atlas AC map was extracted by the PET/MR scanner, and m-Atlas AC map was created using a web service which automatically generates m-Atlas pseudo-CT images. For comparison, the CT-AC map generated by PET/CT was registered and used as gold standard. Using each AC map, PET images were reconstructed from raw data on the TOF-PET/MRI scanner. All PET images were normalized to the SPM5 PET template, and FDG accumulation was quantified in 67 volumes-of-interest (VOIs; automated anatomical labeling (AAL), atlas). Relative (%diff) and absolute differences (|%diff|) between images based on each atlas AC and CT AC were calculated. FDG uptake in all VOIs and generalized merged VOIs were compared using paired t-test and Bland-Altman test. RESULTS: The range of error on m-Atlas in all 804 VOIs was -4.98% ~ 4.09%. |%diff| on m-Atlas was improved by about 30% compared to s-Atlas (s-Atlas vs. m-Atlas; 1.5±1.1% vs. 1.2 ± 0.9%,P< 0.01). In generalized VOIs, %diff on m-Atlas in the temporal lobe and cerebellum were significantly smaller (s-Atlas vs. m-Atlas; temporal lobe, 1.31±1.38% vs. -0.38±1.46%,P< 0.01; cerebellum, 1.46±2.12% vs. -1.07±1.87%,P< 0.01) CONCLUSION: The errors introduced using m-Atlas did not exceed 5 % in any brain region investigated. When compared to the clinical s-Atlas, m-Atlas is more accurate especially in regions close to the skull base.

Type: Article
Title: Multi atlas-based attenuation correction for brain FDG-PET imaging using a TOF-PET/MR scanner- comparison with clinical single atlas- and CT-based attenuation correction
Open access status: An open access version is available from UCL Discovery
DOI: 10.2967/jnumed.115.169045
Publisher version: http://dx.doi.org/10.2967/jnumed.115.169045
Language: English
Additional information: Copyright © 2016 by the Society of Nuclear Medicine and Molecular Imaging, Inc.
Keywords: 18F-FDG, MRI, Neurology, PET, PET/MR, PET/MRI, atlas-based, attenuation correction, brain
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Metabolism and Experi Therapeutics
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1475583
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