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Molecular basis of contact inhibition of locomotion

Roycroft, A; Mayor, R; (2015) Molecular basis of contact inhibition of locomotion. Cellular and Molecular Life Sciences , 73 (6) pp. 1119-1130. 10.1007/s00018-015-2090-0. Green open access

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Abstract

Contact inhibition of locomotion (CIL) is a complex process, whereby cells undergoing a collision with another cell cease their migration towards the colliding cell. CIL has been identified in numerous cells during development including embryonic fibroblasts, neural crest cells and haemocytes and is the driving force behind a range of phenomenon including collective cell migration and dispersion. The loss of normal CIL behaviour towards healthy tissue has long been implicated in the invasion of cancer cells. CIL is a multi-step process that is driven by the tight coordination of molecular machinery. In this review, we shall breakdown CIL into distinct steps and highlight the key molecular mechanisms and components that are involved in driving each step of this process.

Type: Article
Title: Molecular basis of contact inhibition of locomotion
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00018-015-2090-0
Publisher version: http://dx.doi.org/10.1007/s00018-015-2090-0
Additional information: © The Author(s) 2015. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://​creativecommons.​org/​licenses/​by/​4.​0/​), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: Cadherin, Cell adhesion, Cell migration, Cell polarity, Rac, Rho
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1475395
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