UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Practice nurse-led proactive care for chronic depression in primary care: a randomised controlled trial

Buszewicz, M; Griffin, M; McMahon, EM; Walters, K; King, M; (2016) Practice nurse-led proactive care for chronic depression in primary care: a randomised controlled trial. The British Journal of Psychiatry 10.1192/bjp.bp.114.153312. Green open access

[thumbnail of BJPsych_PROCEED_accepted_final.pdf]
Preview
Text
BJPsych_PROCEED_accepted_final.pdf

Download (160kB) | Preview

Abstract

Background: Management of long-term depression is a significant problem in primary care populations with considerable on-going morbidity, but few studies have focused on this group.AimsTo evaluate whether structured, nurse-led proactive care of patients with chronic depression in primary care improves outcomes. Method: Participants with chronic/recurrent major depression or dysthymia were recruited from 42 UK general practices and randomised to general practitioner (GP) treatment as usual or nurse intervention over 2 years (the ProCEED trial, trial registration: ISRCTN36610074). Results: In total 282 people received the intervention and there were 276 controls. At 24 months there was no significant improvement in Beck Depression Inventory (BDI-II) score or quality of life (Euroquol-EQ-VAS), but a significant improvement in functional impairment (Work and Social Activity Schedule, WSAS) of 2.5 (95% CI 0.6-4.3, P = 0.010) in the intervention group. The impact per practice-nurse intervention session was -0.37 (95% CI -0.68 to -0.07, P = 0.017) on the BDI-II score and -0.33 (95% CI -0.55 to -0.10, P = 0.004) on the WSAS score, indicating that attending all 10 intervention sessions could lead to a BDI-II score reduction of 3.7 points compared with controls. Conclusions: The intervention improved functioning in these patients, the majority of whom had complex long-term difficulties, but only had a significant impact on depressive symptoms in those engaging with the full intervention.

Type: Article
Title: Practice nurse-led proactive care for chronic depression in primary care: a randomised controlled trial
Open access status: An open access version is available from UCL Discovery
DOI: 10.1192/bjp.bp.114.153312
Publisher version: http://dx.doi.org/10.1192/bjp.bp.114.153312
Language: English
Additional information: This is an author-produced electronic version of an article accepted for publication in the British Journal of Psychiatry. The definitive publisher-authenticated version is available online at http://bjp.rcpsych.org.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Primary Care and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/1475006
Downloads since deposit
144Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item