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Electrospray synthesis and properties of hierarchically structured PLGA TIPS microspheres for use as controlled release technologies

Malik, SA; Ng, WH; Bowen, J; Tang, J; Gomez, A; Kenyon, AJ; Day, RM; (2016) Electrospray synthesis and properties of hierarchically structured PLGA TIPS microspheres for use as controlled release technologies. Journal of Colloid and Interface Science , 467 pp. 220-229. 10.1016/j.jcis.2016.01.021. Green open access

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Abstract

Microsphere-based controlled release technologies have been utilized for the long-term delivery of proteins, peptides and antibiotics, although their synthesis poses substantial challenges owing to formulation complexities, lack of scalability, and cost. To address these shortcomings, we used the electrospray process as a reproducible, synthesis technique to manufacture highly porous (>94%) microspheres while maintaining control over particle structure and size. Here we report a successful formulation recipe used to generate spherical poly(lactic-co-glycolic) acid (PLGA) microspheres using the electrospray (ES) coupled with a novel thermally induced phase separation (TIPS) process with a tailored Liquid Nitrogen (LN2) collection scheme. We show how size, shape and porosity of resulting microspheres can be controlled by judiciously varying electrospray processing parameters and we demonstrate examples in which the particle size (and porosity) affect release kinetics. The effect of electrospray treatment on the particles and their physicochemical properties are characterized by scanning electron microscopy, confocal Raman microscopy, thermogravimetric analysis and mercury intrusion porosimetry. The microspheres manufactured here have successfully demonstrated long-term delivery (i.e. 1week) of an active agent, enabling sustained release of a dye with minimal physical degradation and have verified the potential of scalable electrospray technologies for an innovative TIPS-based microsphere production protocol.

Type: Article
Title: Electrospray synthesis and properties of hierarchically structured PLGA TIPS microspheres for use as controlled release technologies
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jcis.2016.01.021
Publisher version: http://dx.doi.org/10.1016/j.jcis.2016.01.021
Language: English
Additional information: ©2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Electrosprays, Microspheres, Poly(lactic-co-glycolic acid) (PLGA), Thermally induced phase separation (TIPS)
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Electronic and Electrical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1474784
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