Jin, M;
Li, W;
Spillane, DEM;
Geraldes, CFGC;
Williams, GR;
Bligh, SWA;
(2016)
Hydroxy double salts intercalated with Mn(II) complexes as potential contrast agents.
Solid State Sciences
, 53
pp. 9-16.
10.1016/j.solidstatesciences.2015.12.024.
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Abstract
A series of Mn(II) aminophosphonate complexes were successfully synthesized and intercalated into the hydroxy double salt [Zn5(OH)8]Cl2·yH2O. Complex incorporation led to an increase in the interlayer spacing from 7.8 to 10–12 Å. Infrared spectroscopy showed the presence of the characteristic vibration peaks of the Mn(II) complexes in the intercalates' spectra, indicating successful incorporation. The complex-loaded composites had somewhat lower proton relaxivities than the pure complexes. Nevertheless, these intercalates may have use as MRI contrast agents for patients with poor kidney function, where traditional Gd(III)-based contrast agents cause severe renal failure.
| Type: | Article |
|---|---|
| Title: | Hydroxy double salts intercalated with Mn(II) complexes as potential contrast agents |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.solidstatesciences.2015.12.024 |
| Publisher version: | http://dx.doi.org/10.1016/j.solidstatesciences.201... |
| Language: | English |
| Additional information: | © 2016 Elsevier Masson SAS. This manuscript is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0. Access may be initially restricted by the publisher. |
| Keywords: | Hydroxy double salt; Magnetic resonance imaging; Contrast agent; Mn complexes |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1474511 |
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