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Challenges in the clinical assessment of novel tuberculosis drugs

Dooley, KE; Phillips, PP; Nahid, P; Hoelscher, M; (2016) Challenges in the clinical assessment of novel tuberculosis drugs. Advanced Drug Delivery Reviews , 102 pp. 116-122. 10.1016/j.addr.2016.01.014. Green open access

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Abstract

To effectively tackle the global TB epidemic, novel treatment strategies are critically needed to shorten the duration of TB therapy and treat drug-resistant TB. Drug development for TB, stymied for decades, has enjoyed a renaissance over the past several years. However, development of new TB regimens is hindered by the limitations in our understanding and use of preclinical models; the paucity of accurate, early surrogate markers of cure, and challenges in untangling the individual contributions of drugs to multidrug regimens in a complex, multi-compartment disease. Lack of profit motive, advocacy, and imagination has contributed mightily to the dearth of drugs we have on the shelf to treat this ancient disease. Areas that will speed the development of new regimens for TB include novel murine and in vitro pharmacodynamics models, clinical endpoints that are not culture-based, innovative clinical trial designs, and an infusion of much-needed funding.

Type: Article
Title: Challenges in the clinical assessment of novel tuberculosis drugs
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.addr.2016.01.014
Publisher version: http://dx.doi.org/10.1016/j.addr.2016.01.014
Language: English
Additional information: Copyright © 2016. This manuscript version is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International licence (CC BY-NC-ND 4.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licences are available at http://creativecommons.org/licenses/by/4.0. Access may be initially restricted by the publisher.
Keywords: Hollow fiber model, mouse model, pharmacokinetic/pharmacodynamic, translational science, trial design, tuberculosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/1474494
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