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Validation of NODDI estimation of dispersion anisotropy in V1 of the human neocortex

Tariq, M; Kleinnijenhuis, M; van Cappellen van Walsum, A-M; Zhang, H; (2015) Validation of NODDI estimation of dispersion anisotropy in V1 of the human neocortex. In: Proceedings of Organization for Human Brain Mapping (OHBM), 21st Annual Meeting. OHBM: Honolulu, Hawaii. Green open access

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Abstract

This work validates the estimation of neurite dispersion anisotropy in the brain, using Bingham-NODDI [1], an extension of the diffusion MRI technique called NODDI [2]. The original NODDI provides indices of neurite (axons and dendrites) morphology that are sensitive and specific to microstructural changes [3-7]. Bingham-NODDI additionally allows the estimation of neurite dispersion anisotropy, which can enhance the accuracy of tractography algorithms [8]. The in vivo feasibility of Bingham-NODDI has been evaluated in [1]. The present study validates its indices using high-resolution ex vivo imaging data of the human primary visual cortex (V1), a well characterised region of the neocortex known to include fibres that fan or bend into the cortical layers.

Type: Proceedings paper
Title: Validation of NODDI estimation of dispersion anisotropy in V1 of the human neocortex
Event: Organization for Human Brain Mapping (OHBM), 21st Annual Meeting
Location: Honolulu, Hawaii
Dates: 14 June 2015 - 18 June 2015
Open access status: An open access version is available from UCL Discovery
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: https://discovery.ucl.ac.uk/id/eprint/1474345
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