UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Dynamic risk control by human nucleus accumbens

Nachev, P; Lopez-Sosa, F; Gonzalez-Rosa, JJ; Galarza, A; Avecillas, J; Pineda-Pardo, JA; Lopez-Ibor, JJ; ... Strange, B; + view all (2015) Dynamic risk control by human nucleus accumbens. Brain , 138 (12) pp. 3496-3502. 10.1093/brain/awv285. Green open access

[thumbnail of Dynamic risk control by human nucleus accumbens.pdf]
Preview
Text
Dynamic risk control by human nucleus accumbens.pdf

Download (938kB) | Preview

Abstract

Real-world decisions about reward often involve a complex counterbalance of risk and value. Although the nucleus accumbens has been implicated in the underlying neural substrate, its criticality to human behaviour remains an open question, best addressed with interventional methodology that probes the behavioural consequences of focal neural modulation. Combining a psychometric index of risky decision-making with transient electrical modulation of the nucleus accumbens, here we reveal profound, highly dynamic alteration of the relation between probability of reward and choice during therapeutic deep brain stimulation in four patients with treatment-resistant psychiatric disease. Short-lived phasic electrical stimulation of the region of the nucleus accumbens dynamically altered risk behaviour, transiently shifting the psychometric function towards more risky decisions only for the duration of stimulation. A critical, on-line role of human nucleus accumbens in dynamic risk control is thereby established.

Type: Article
Title: Dynamic risk control by human nucleus accumbens
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/brain/awv285
Publisher version: http://dx.doi.org/10.1093/brain/awv285
Language: English
Additional information: © The Author (2015). Published by Oxford University Press on behalf of the Guarantors of Brain. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: decision-making, nucleus accumbens, reward, risk, subcortical electrical stimulation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
URI: https://discovery.ucl.ac.uk/id/eprint/1474329
Downloads since deposit
98Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item