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Bioreactors for Tissue Engineering: An Update

Kalaskar, D; (2016) Bioreactors for Tissue Engineering: An Update. Biochemical Engineering Journal , 109 pp. 268-281. 10.1016/j.bej.2016.01.018. Green open access

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Abstract

One of the greatest puzzles in wound healing is how to substitute or replace the defect caused by loss and damaged tissue or organs. In regenerative medicine, Tissue Engineering has been proposed to supply this demand by generating tissues in vitro. Bioreactors are the key to translate these cells and tissue-based constructs into large-scale biological products that are clinically effective, safe and financially pliable. In this review, we summarise the different up-to-date bioreactor designs being used for different cell types and special design scaffolds, and highlight advantages of different bioreactors, current challenges and the future trends. It is our belief that with efforts combined from multiple disciplinary participants, a novel bioreactor system that is capable of fast, large scale tissue culture would come about in near future.

Type: Article
Title: Bioreactors for Tissue Engineering: An Update
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bej.2016.01.018
Publisher version: http://dx.doi.org/10.1016/j.bej.2016.01.018
Language: English
Additional information: © Elsevier, 2016. After an initial embargo period, this article will be made available under a Creative Commons Attribution Non-commercial Non-derivative 3.0 licence (CC BY-NC-ND 3.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated.
Keywords: Bioreactor, Tissue Engineering
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
URI: https://discovery.ucl.ac.uk/id/eprint/1474274
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