Attwell, D;
Mishra, A;
Hall, CN;
O'Farrell, FM;
Dalkara, T;
(2016)
What is a pericyte?
Journal of Cerebral Blood Flow & Metabolism
, 36
(2)
10.1177/0271678X15610340.
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Abstract
Pericytes, spatially isolated contractile cells on capillaries, have been reported to control cerebral blood flow physiologically, and to limit blood flow after ischaemia by constricting capillaries and then dying. Paradoxically, a recent paper dismisses the idea of pericytes controlling cerebral blood flow, despite confirming earlier data showing a role for pericytes. We show that these discrepancies are apparent rather than real, and depend on the new paper defining pericytes differently from previous reports. An objective definition of different sub-classes of pericyte along the capillary bed is needed to develop novel therapeutic approaches for stroke and disorders caused by pericyte malfunction.
| Type: | Article |
|---|---|
| Title: | What is a pericyte? |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/0271678X15610340 |
| Publisher version: | https://doi.org/10.1177/0271678X15610340 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Pericyte, blood–brain barrier, capillary, cerebral blood flow, stroke |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1474097 |
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