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Utilising inorganic nanocarriers for gene delivery

Loh, XJ; Lee, T-C; Dou, Q; Deen, GR; (2016) Utilising inorganic nanocarriers for gene delivery. Biomaterials Science , 4 (1) pp. 70-86. 10.1039/C5BM00277J. Green open access

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Abstract

The delivery of genetic materials into cells to elicit cellular responses has been extensively studied by biomaterials scientists globally. Many materials such as lipids, peptides, viruses, synthetically modified cationic polymers and certain inorganic nanomaterials could be used to complex the negatively charged plasmids and deliver the formed package into cells. The recent literature on the delivery of genetic materials utilising inorganic nanoparticles is carefully examined in this review. We have picked out the most relevant references and concisely summarised the findings with illustrated examples. We further propose alternative approaches and suggest future pathways towards the practical use of multifunctional nanocarriers.

Type: Article
Title: Utilising inorganic nanocarriers for gene delivery
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/C5BM00277J
Publisher version: http://dx.doi.org/10.1039/C5BM00277J
Language: English
Additional information: © Royal Society of Chemistry 2016
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > MAPS Faculty Office
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > MAPS Faculty Office > Institute for Materials Discovery
URI: https://discovery.ucl.ac.uk/id/eprint/1474026
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