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Non-Immunosuppressive Cyclosporin Derivates as Antiviral Agents

Selwood, DL; Towers, G; Rasaiyaah, J; (2014) Non-Immunosuppressive Cyclosporin Derivates as Antiviral Agents. WO2014132084. Green open access

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Abstract

A cyclosporin derivative which is a compound of formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment or prevention of a viral infection: wherein: A represents (F(II)) or (F(III)) B represents methyl or ethyl, R2 represents ethyl or isopropyl, R4 represents -CH2CH(CH3)CH3, -CH2CH(CH3)CH2CH3, -CH(CH3)CH3 or -CH(CH3)CH2CH3, and either (a) one of R1 and R1* represents hydrogen and the other represents methyl, and R3 represents -L3-G3, or (b) one of R1 and R1* represents hydrogen and the other represents and R3 represents H, wherein L1 and L3 represent a direct bond, a C1-C6 alkylene group or a C2-C6 alkenylene group; and G1 and G3 represent a hydrogen atom, a -COOR' group, or a phenyl moiety which is unsubstituted or substituted by one, two or three substituents selected from a halogen atom, a -COOR' group, a -CONR'R'' group, a hydroxyl group, a C1-C6 alkyl group and a C1-C6 alkoxy group, wherein R' and R'' are the same or different and represent hydrogen or a C1-C6 alkyl group, provided that (a) G1 does not represent a hydrogen atom when Li represents a direct bond or methylene, and (b) G3 does not represent a hydrogen atom when L3 represents a direct bond or methylene.

Type: Patent
Title: Non-Immunosuppressive Cyclosporin Derivates as Antiviral Agents
Dates: 04 September 2014
Identifier: WO2014132084
Open access status: An open access version is available from UCL Discovery
Publisher version: https://patentscope.wipo.int/search/en/detail.jsf?...
Language: English
Additional information: Applies in the following countries: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1473873
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