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Integration of genetic and epigenetic markers for risk stratification: opportunities and challenges

Pashayan, N; Reisel, D; Widschwendter, M; (2016) Integration of genetic and epigenetic markers for risk stratification: opportunities and challenges. Personalized Medicine , 13 (2) pp. 93-95. 10.2217/pme.15.53. Green open access

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Abstract

Common genetic susceptibility variants could be used for risk stratification in risk-tailored cancer screening and prevention programmes. Combining genetic variants with environmental risk factors would improve risk stratification. Epigenetic changes are surrogate markers of environmental exposures during individual's lifetime. Integrating epigenetic markers, in lieu of environmental exposure data, with genetic markers would potentially improve risk stratification. Epigenetic changes are reversible and acquired gradually, providing potentials for prevention and early detection strategies. The epigenetic changes are tissue-specific and stage-of-development-specific, raising challenges in choice of sample and timing for evaluation of cancer-associated changes. The Horizon 2020 funded research programme, FORECEE, using empirical data, will investigate the value of integration of epigenomics with genomics for risk prediction and prevention of women-specific cancers.

Type: Article
Title: Integration of genetic and epigenetic markers for risk stratification: opportunities and challenges
Open access status: An open access version is available from UCL Discovery
DOI: 10.2217/pme.15.53
Publisher version: http://dx.doi.org/10.2217/pme.15.53
Language: English
Additional information: Copyright © 2016 Future Medicine Ltd. This is the accepted manuscript version of the article published in Personalized Medicine; the final published version can be found at http://dx.doi.org/10.2217/pme.15.53
Keywords: Risk assessment, cancer, epigenetics, polygenic risk, risk stratification
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Applied Health Research
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Womens Cancer
URI: https://discovery.ucl.ac.uk/id/eprint/1473758
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