Yoder, AD;
Chan, LM;
dos Reis, M;
Larsen, PA;
Campbell, CR;
Rasoloarison, R;
Barrett, M;
... Yang, Z; + view all
(2014)
Molecular Evolutionary Characterization of a V1R Subfamily Unique to Strepsirrhine Primates.
Genome Biology and Evolution
, 6
(1)
pp. 213-227.
10.1093/gbe/evu006.
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Abstract
Vomeronasal receptor genes have frequently been invoked as integral to the establishment and maintenance of species boundaries among mammals due to the elaborate one-to-one correspondence between semiochemical signals and neuronal sensory inputs. Here, we report the most extensive sample of vomeronasal receptor class 1 (V1R) sequences ever generated for a diverse yet phylogenetically coherent group of mammals, the tooth-combed primates (suborder Strepsirrhini). Phylogenetic analysis confirms our intensive sampling from a single V1R subfamily, apparently unique to the strepsirrhine primates. We designate this subfamily as V1Rstrep. The subfamily retains extensive repertoires of gene copies that descend from an ancestral gene duplication that appears to have occurred prior to the diversification of all lemuriform primates excluding the basal genusDaubentonia (the aye-aye). We refer to the descendent clades as V1Rstrep-a and V1Rstrep-b. Comparison of the two clades reveals different amino acid compositions corresponding to the predicted ligand-binding site and thus potentially to altered functional profiles between the two. In agreement with previous studies of the mouse lemur (genus, Microcebus), the majority of V1Rstrep gene copies appear to be intact and under strong positive selection, particularly within transmembrane regions. Finally, despite the surprisingly high number of gene copies identified in this study, it is nonetheless probable that V1R diversity remains underestimated in these nonmodel primates and that complete characterization will be limited until high-coverage assembled genomes are available.
| Type: | Article |
|---|---|
| Title: | Molecular Evolutionary Characterization of a V1R Subfamily Unique to Strepsirrhine Primates |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/gbe/evu006 |
| Publisher version: | http://dx.doi.org/10.1093/gbe/evu006 |
| Language: | English |
| Additional information: | Copyright The Author(s) 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | G-protein-coupled receptors, lemurs, positive selection, olfaction, chemosensory genes, gene family evolution. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1473663 |
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