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Dispersion-enhanced solute transport in a cell-seeded hollow fibre membrane bioreactor

Pearson, NC; Shipley, RJ; Waters, SL; Oliver, JM; (2016) Dispersion-enhanced solute transport in a cell-seeded hollow fibre membrane bioreactor. Journal of Engineering Mathematics , 99 (1) pp. 29-63. 10.1007/s10665-015-9819-5. Green open access

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Abstract

We present a matched asymptotic analysis of the fluid flow and solute transport in a small aspect ratio hollow fibre membrane bioreactor. A two-dimensional domain is assumed for simplicity, enabling greater understanding of the typical behaviours of the system in a setup which is analytically tractable. The model permits analysis related to Taylor dispersion problems, and allows us to predict the dependence of the mean solute uptake and solute exposure time on key parameters such as the inlet fluid fluxes, porous membrane porosity and cell layer porosity and width, which could be controlled or measured experimentally.

Type: Article
Title: Dispersion-enhanced solute transport in a cell-seeded hollow fibre membrane bioreactor
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s10665-015-9819-5
Publisher version: http://dx.doi.org/10.1007/s10665-015-9819-5
Language: English
Additional information: Copyright © Springer Science+BusinessMedia Dordrecht, 2016. All rights reserved. The final publication is available at Springer via http://dx.doi.org/10.1007/s10665-015-9819-5
Keywords: Asymptotic reduction, Taylor dispersion, Tissue engineering
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1473339
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