UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Calcium-activated potassium channels at nodes of Ranvier secure axonal spike propagation

Gründemann, J; Clark, BA; (2015) Calcium-activated potassium channels at nodes of Ranvier secure axonal spike propagation. Cell Reports , 12 (11) pp. 1715-1722. 10.1016/j.celrep.2015.08.022. Green open access

[thumbnail of 1-s2.0-S2211124715008931-main.pdf]
Preview
Text
1-s2.0-S2211124715008931-main.pdf

Download (6MB) | Preview

Abstract

Functional connectivity between brain regions relies on long-range signaling by myelinated axons. This is secured by saltatory action potential propagation that depends fundamentally on sodium channel availability at nodes of Ranvier. Although various potassium channel types have been anatomically localized to myelinated axons in the brain, direct evidence for their functional recruitment in maintaining node excitability is scarce. Cerebellar Purkinje cells provide continuous input to their targets in the cerebellar nuclei, reliably transmitting axonal spikes over a wide range of rates, requiring a constantly available pool of nodal sodium channels. We show that the recruitment of calcium-activated potassium channels (IK, KCa3.1) by local, activity-dependent calcium (Ca2+) influx at nodes of Ranvier via a T-type voltage-gated Ca2+ current provides a powerful mechanism that likely opposes depolarizing block at the nodes and is thus pivotal to securing continuous axonal spike propagation in spontaneously firing Purkinje cells.

Type: Article
Title: Calcium-activated potassium channels at nodes of Ranvier secure axonal spike propagation
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.celrep.2015.08.022
Publisher version: http://dx.doi.org/10.1016/j.celrep.2015.08.022
Additional information: Copyright © 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/1473330
Downloads since deposit
94Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item