Brunner, EJ;
Shipley, MJ;
Ahmadi-Abhari, S;
Tabak, AG;
McEniery, CM;
Wilkinson, IB;
Marmot, MG;
... Kivimaki, M; + view all
(2015)
Adiposity, obesity, and arterial aging: longitudinal study of aortic stiffness in the Whitehall II cohort.
Hypertension
, 66
(2)
pp. 294-300.
10.1161/HYPERTENSIONAHA.115.05494.
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Abstract
We sought to determine whether adiposity in later midlife is an independent predictor of accelerated stiffening of the aorta. Whitehall II study participants (3789 men; 1383 women) underwent carotid-femoral applanation tonometry at the mean age of 66 and again 4 years later. General adiposity by body mass index, central adiposity by waist circumference and waist:hip ratio, and fat mass percent by body impedance were assessed 5 years before and at baseline. In linear mixed models adjusted for age, sex, ethnicity, and mean arterial pressure, all adiposity measures were associated with aortic stiffening measured as increase in pulse wave velocity (PWV) between baseline and follow-up. The associations were similar in the metabolically healthy and unhealthy, according to Adult Treatment Panel-III criteria excluding waist circumference. C-reactive protein and interleukin-6 levels accounted for part of the longitudinal association between adiposity and PWV change. Adjusting for chronic disease, antihypertensive medication and risk factors, standardized effects of general and central adiposity and fat mass percent on PWV increase (m/s) were similar (0.14, 95% confidence interval: 0.05-0.24, P=0.003; 0.17, 0.08-0.27, P<0.001; 0.14, 0.05-0.22, P=0.002, respectively). Previous adiposity was associated with aortic stiffening independent of change in adiposity, glycaemia, and lipid levels across PWV assessments. We estimated that the body mass index-linked PWV increase will account for 12% of the projected increase in cardiovascular risk because of high body mass index. General and central adiposity in later midlife were strong independent predictors of aortic stiffening. Our findings suggest that adiposity is an important and potentially modifiable determinant of arterial aging.
| Type: | Article |
|---|---|
| Title: | Adiposity, obesity, and arterial aging: longitudinal study of aortic stiffness in the Whitehall II cohort |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1161/HYPERTENSIONAHA.115.05494 |
| Publisher version: | http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.0549... |
| Language: | English |
| Additional information: | © 2015 The Authors. Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited. |
| Keywords: | aging, arterial stiffness, epidemiology, longitudinal studies, obesity, Adiposity, Adult, Aging, Body Mass Index, C-Reactive Protein, Cohort Studies, Female, Humans, Interleukin-6, London, Longitudinal Studies, Male, Middle Aged, Obesity, Predictive Value of Tests, Pulse Wave Analysis, Vascular Stiffness, Waist Circumference, Waist-Hip Ratio |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1473124 |
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