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Physiological phenotyping of dementias using emotional sounds

Fletcher, PD; Nicholas, JM; Shakespeare, TJ; Downey, LE; Golden, HL; Agustus, JL; Clark, CN; ... Warren, JD; + view all (2015) Physiological phenotyping of dementias using emotional sounds. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring , 1 (2) pp. 170-178. 10.1016/j.dadm.2015.02.003. Green open access

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Abstract

Introduction: Emotional behavioral disturbances are hallmarks of many dementias but their pathophysiology is poorly understood. Here we addressed this issue using the paradigm of emotionally salient sounds. Methods: Pupil responses and affective valence ratings for nonverbal sounds of varying emotional salience were assessed in patients with behavioral variant frontotemporal dementia (bvFTD) (n=14), semantic dementia (SD) (n=10), progressive nonfluent aphasia (PNFA) (n=12), and AD (n=10) versus healthy age-matched individuals (n=26). Results: Referenced to healthy individuals, overall autonomic reactivity to sound was normal in Alzheimer's disease (AD) but reduced in other syndromes. Patients with bvFTD, SD, and AD showed altered coupling between pupillary and affective behavioral responses to emotionally salient sounds. Discussion: Emotional sounds are a useful model system for analyzing how dementias affect the processing of salient environmental signals, with implications for defining pathophysiological mechanisms and novel biomarker development.

Type: Article
Title: Physiological phenotyping of dementias using emotional sounds
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.dadm.2015.02.003
Publisher version: http://dx.doi.org/10.1016/j.dadm.2015.02.003
Language: English
Additional information: © 2015 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > IoN Central Administration
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1473095
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