Fisher, JP;
(2015)
Optimising antibody dependent killing of neuroblastoma.
Doctoral thesis , UCL (University College London).
Abstract
Human γδT lymphocytes have potent anti-tumour efficacy in vitro and have some clinical efficacy against solid and haematological cancers. γδT cells of Vδ1+, Vδ2+ or Vδ1-/Vδ2- subsets expanded and purified from the blood of healthy donors or childhood cancer patients have distinct memory and activation phenotypes, and anti- tumour functions. Second generation chimeric antigen receptors (CARs) can enhance γδT cell anti-tumour efficacy but lead to on-target off-tumour toxicity. First generation co-stimulatory CARs also enhance anti-tumour cytotoxicity of γδT cells but avoid on-target off-tumour toxicity, suggesting a possible clinical approach to targeting a wide range of tumour associated antigens.
| Type: | Thesis (Doctoral) |
|---|---|
| Title: | Optimising antibody dependent killing of neuroblastoma |
| Event: | UCL |
| Language: | English |
| Keywords: | immunology, cancer, gamma-delta T cells, gdT cells, immunotherapy, neuroblastoma |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1472980 |
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