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Decomposition of spontaneous fluctuations in tumour oxygenation using BOLD MRI and independent component analysis

Gonçalves, MR; Johnson, SP; Ramasawmy, R; Pedley, RB; Lythgoe, MF; Walker-Samuel, S; (2015) Decomposition of spontaneous fluctuations in tumour oxygenation using BOLD MRI and independent component analysis. British Journal of Cancer , 113 (8) pp. 1168-1177. 10.1038/bjc.2015.270. Green open access

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Abstract

Solid tumours can undergo cycles of hypoxia, followed by reoxygenation, which can have significant implications for the success of anticancer therapies. A need therefore exists to develop methods to aid its detection and to further characterise its biological basis. We present here a novel method for decomposing systemic and tumour-specific contributions to fluctuations in tumour deoxyhaemoglobin concentration, based on magnetic resonance imaging measurements.

Type: Article
Title: Decomposition of spontaneous fluctuations in tumour oxygenation using BOLD MRI and independent component analysis
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/bjc.2015.270
Publisher version: http://dx.doi.org/10.1038/bjc.2015.270
Additional information: This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1472851
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