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Calcium signaling as a mediator of cell energy demand and a trigger to cell death

Bhosale, G; Sharpe, JA; Sundier, SY; Duchen, MR; (2015) Calcium signaling as a mediator of cell energy demand and a trigger to cell death. Annals of the New York Academy of Sciences , 1350 (1) pp. 107-116. 10.1111/nyas.12885. Green open access

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Abstract

Calcium signaling is pivotal to a host of physiological pathways. A rise in calcium concentration almost invariably signals an increased cellular energy demand. Consistent with this, calcium signals mediate a number of pathways that together serve to balance energy supply and demand. In pathological states, calcium signals can precipitate mitochondrial injury and cell death, especially when coupled to energy depletion and oxidative or nitrosative stress. This review explores the mechanisms that couple cell signaling pathways to metabolic regulation or to cell death. The significance of these pathways is exemplified by pathological case studies, such as those showing loss of mitochondrial calcium uptake 1 in patients and ischemia/reperfusion injury.

Type: Article
Title: Calcium signaling as a mediator of cell energy demand and a trigger to cell death
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/nyas.12885
Publisher version: http://dx.doi.org/10.1111/nyas.12885
Language: English
Additional information: © 2015 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals Inc. on behalf of The New York Academy of Sciences. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: MICU1, calcium signaling, cell death, ischemia/reperfusion injury, mitochondrial calcium uptake, mitochondrial permeability transition pore
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1472687
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