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From the Reticuloendothelial to Mononuclear Phagocyte System - The Unaccounted Years

Yona, S; Gordon, S; (2015) From the Reticuloendothelial to Mononuclear Phagocyte System - The Unaccounted Years. Frontiers in Immunology , 6 , Article 328. 10.3389/fimmu.2015.00328. Green open access

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Abstract

It is over 125 years since Ilya Metchnikoff described the significance of phagocytosis. In this review, we examine the early origins and development of macrophage research continuing after his death in 1916, through the period of the reticuloendothelial system. Studies on these cells resulted in a substantial literature spanning immunology, hematology, biochemistry, and pathology. Early histological studies on morphology and in situ labeling laid the foundations to appreciate the diversity and functional capacity of these cells in the steady state and during pathology. We complete this phagocyte retrospective with the establishment of the mononuclear phagocyte system nomenclature half a century ago.

Type: Article
Title: From the Reticuloendothelial to Mononuclear Phagocyte System - The Unaccounted Years
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fimmu.2015.00328
Publisher version: http://dx.doi.org/10.3389/fimmu.2015.00328
Language: English
Additional information: © 2015 Yona and Gordon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: Metchnikoff, dendritic cells, inflammation, macrophage, monocyte, phagocytosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1472597
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