Virological failure and development of new resistance mutations according to CD4 count at combination antiretroviral therapy initiation

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Virological failure and development of new resistance mutations according to CD4 count at combination antiretroviral therapy initiation

Jose, S; Quinn, K; Dunn, D; Cox, A; Sabin, C; Fidler, S; UK CHIC, and UK HDRD Steering Committees; (2016) Virological failure and development of new resistance mutations according to CD4 count at combination antiretroviral therapy initiation. HIV Medicine , 17 (5) pp. 368-372. 10.1111/hiv.12302. Green open access

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Abstract

No randomized controlled trials have yet reported an individual patient benefit of initiating combination antiretroviral therapy (cART) at CD4 counts > 350 cells/μL. It is hypothesized that earlier initiation of cART in asymptomatic and otherwise healthy individuals may lead to poorer adherence and subsequently higher rates of resistance development.

Type:	Article
Title:	Virological failure and development of new resistance mutations according to CD4 count at combination antiretroviral therapy initiation
Open access status:	An open access version is available from UCL Discovery
DOI:	10.1111/hiv.12302
Publisher version:	http://dx.doi.org/10.1111/hiv.12302
Language:	English
Additional information:	© 2015 The Authors. HIV Medicine published by John Wiley & Sons Ltd on behalf of British HIV Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords:	CD4 count, HIV resistance, antiretroviral therapy, virological failure
UCL classification:	UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of the Built Environment UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of the Built Environment > Centre for Advanced Spatial Analysis
URI:	https://discovery.ucl.ac.uk/id/eprint/1472505

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