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Using Gene Ontology to describe the role of the neurexin-neuroligin-SHANK complex in human, mouse and rat and its relevance to autism

Patel, S; Roncaglia, P; Lovering, RC; (2015) Using Gene Ontology to describe the role of the neurexin-neuroligin-SHANK complex in human, mouse and rat and its relevance to autism. BMC Bioinformatics , 16 , Article 186. 10.1186/s12859-015-0622-0. Green open access

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Abstract

People with an autistic spectrum disorder (ASD) display a variety of characteristic behavioral traits, including impaired social interaction, communication difficulties and repetitive behavior. This complex neurodevelopment disorder is known to be associated with a combination of genetic and environmental factors. Neurexins and neuroligins play a key role in synaptogenesis and neurexin-neuroligin adhesion is one of several processes that have been implicated in autism spectrum disorders.

Type: Article
Title: Using Gene Ontology to describe the role of the neurexin-neuroligin-SHANK complex in human, mouse and rat and its relevance to autism
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/s12859-015-0622-0
Publisher version: http://dx.doi.org/10.1186/s12859-015-0622-0
Language: English
Additional information: © 2015 Patel et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Keywords: Animals, Autistic Disorder, Cell Adhesion Molecules, Neuronal, Cell Physiological Phenomena, Gene Ontology, Genome, Genomics, High-Throughput Nucleotide Sequencing, Humans, Membrane Potentials, Mice, Models, Molecular, Nerve Tissue Proteins, Phenotype, Rats, Social Behavior, Synapses, Synaptic Potentials
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: https://discovery.ucl.ac.uk/id/eprint/1472457
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