Mauri, C;
Menon, M;
(2015)
The expanding family of regulatory B cells.
International Immunology
, 27
(10)
pp. 479-486.
10.1093/intimm/dxv038.
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Abstract
Over the last decade it has become evident that in addition to producing antibody, B cells activate the immune system by producing cytokines and via antigen presentation. In addition, B cells also exhibit immunosuppressive functions via diverse regulatory mechanisms. This subset of B cells, known as regulatory B cells (Bregs), contributes to the maintenance of tolerance, primarily via the production of IL-10. Studies in experimental animal models, as well as in patients with autoimmune diseases, have identified multiple Breg subsets exhibiting diverse mechanisms of immune suppression. In this review, we describe the different Breg subsets identified in mice and humans, and their diverse mechanisms of suppression in different disease settings.
| Type: | Article |
|---|---|
| Title: | The expanding family of regulatory B cells |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/intimm/dxv038 |
| Publisher version: | http://dx.doi.org/10.1093/intimm/dxv038 |
| Additional information: | © The Author 2015. Published by Oxford University Press on behalf of The Japanese Society for Immunology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited |
| Keywords: | B cell, Bregs, IL-10, human, immune-suppression, mouse, regulation, regulatory B cells, subsets |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1472446 |
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