Schnupp, JW;
Garcia-Lazaro, JA;
Lesica, NA;
(2015)
Periodotopy in the gerbil inferior colliculus: local clustering rather than a gradient map.
Frontiers in Neural Circuits
, 9
, Article 37. 10.3389/fncir.2015.00037.
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Abstract
Periodicities in sound waveforms are widespread, and shape important perceptual attributes of sound including rhythm and pitch. Previous studies have indicated that, in the inferior colliculus (IC), a key processing stage in the auditory midbrain, neurons tuned to different periodicities might be arranged along a periodotopic axis which runs approximately orthogonal to the tonotopic axis. Here we map out the topography of frequency and periodicity tuning in the IC of gerbils in unprecedented detail, using pure tones and different periodic sounds, including click trains, sinusoidally amplitude modulated (SAM) noise and iterated rippled noise. We found that while the tonotopic map exhibited a clear and highly reproducible gradient across all animals, periodotopic maps varied greatly across different types of periodic sound and from animal to animal. Furthermore, periodotopic gradients typically explained only about 10% of the variance in modulation tuning between recording sites. However, there was a strong local clustering of periodicity tuning at a spatial scale of ca. 0.5 mm, which also differed from animal to animal.
| Type: | Article |
|---|---|
| Title: | Periodotopy in the gerbil inferior colliculus: local clustering rather than a gradient map |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fncir.2015.00037 |
| Publisher version: | http://dx.doi.org/10.3389/fncir.2015.00037 |
| Language: | English |
| Additional information: | Copyright © 2015 Schnupp, Garcia-Lazaro and Lesica. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | auditory midbrain, functional anatomy, inferior colliculus, periodic sound, periodotopy, pitch, tonotopy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1472424 |
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