UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

The CXCL12/CXCR4 Axis Plays a Critical Role in Coronary Artery Development

Ivins, S; Chappell, J; Vernay, B; Suntharalingham, J; Martineau, A; Mohun, TJ; Scambler, PJ; (2015) The CXCL12/CXCR4 Axis Plays a Critical Role in Coronary Artery Development. Developmental Cell , 33 (4) pp. 455-468. 10.1016/j.devcel.2015.03.026. Green open access

[img]
Preview
Text
1-s2.0-S1534580715002427-main.pdf

Download (7MB) | Preview

Abstract

The chemokine CXCL12 and its receptor CXCR4 have many functions during embryonic and post-natal life. We used murine models to investigate the role of CXCL12/CXCR4 signaling in cardiac development and found that embryonic Cxcl12-null hearts lacked intra-ventricular coronary arteries (CAs) and exhibited absent or misplaced CA stems. We traced the origin of this phenotype to defects in the early stages of CA stem formation. CA stems derive from the peritruncal plexus, an encircling capillary network that invades the wall of the developing aorta. We showed that CXCL12 is present at high levels in the outflow tract, while peritruncal endothelial cells (ECs) express CXCR4. In the absence of CXCL12, ECs were abnormally localized and impaired in their ability to anastomose with the aortic lumen. We propose that CXCL12 is required for connection of peritruncal plexus ECs to the aortic endothelium and thus plays a vital role in CA formation.

Type: Article
Title: The CXCL12/CXCR4 Axis Plays a Critical Role in Coronary Artery Development
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.devcel.2015.03.026
Publisher version: http://dx.doi.org/10.1016/j.devcel.2015.03.026
Language: English
Additional information: © 2015 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Keywords: Animals, Aorta, Cells, Cultured, Chemokine CXCL12, Coronary Vessels, Embryo, Mammalian, Endothelium, Vascular, Female, Heart, In Situ Hybridization, Male, Mice, Mice, Knockout, Organogenesis, Receptors, CXCR4, Signal Transduction
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Genetics and Genomic Medicine Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1472418
Downloads since deposit
75Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item