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Non-V delta 2 gamma delta T lymphocytes as effectors of cancer immunotherapy

Fisher, J; Kramer, AM; Gustafsson, K; Anderson, J; (2015) Non-V delta 2 gamma delta T lymphocytes as effectors of cancer immunotherapy. Oncoimmunology , 4 (3) , Article e973808. 10.4161/2162402X.2014.973808. Green open access

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Abstract

Gamma delta T cells (γδT) are potent mediators of antitumor cytotoxicity and have shown promising efficacy in early phase clinical trials. Most is known about the tumoricidal properties of cells bearing the Vδ2 T cell receptor chain, but recent studies have demonstrated that cells with the Vδ1 chain and those with neither Vδ1 nor Vδ2 chains have properties which may make them more attractive anticancer effectors in adoptive immunotherapy.

Type: Article
Title: Non-V delta 2 gamma delta T lymphocytes as effectors of cancer immunotherapy
Open access status: An open access version is available from UCL Discovery
DOI: 10.4161/2162402X.2014.973808
Publisher version: http://dx.doi.org/10.4161/2162402X.2014.973808
Language: English
Additional information: © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
Keywords: Vdelta-1, gamma-delta T cell, neuroblastoma, ovarian cancer, preclinical
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1472203
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