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Effect of geometry on drug release from 3D printed tablets

Goyanes, A; Robles Martinez, P; Buanz, A; Basit, AW; Gaisford, S; (2015) Effect of geometry on drug release from 3D printed tablets. International Journal of Pharmaceutics , 494 (2) pp. 657-663. 10.1016/j.ijpharm.2015.04.069. Green open access

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Abstract

© 2015 Elsevier B.V. All rights reserved. The aim of this work was to explore the feasibility of combining hot melt extrusion (HME) with 3D printing (3DP) technology, with a view to producing different shaped tablets which would be otherwise difficult to produce using traditional methods. A filament extruder was used to obtain approx. 4% paracetamol loaded filaments of polyvinyl alcohol with characteristics suitable for use in fused-deposition modelling 3DP. Five different tablet geometries were successfully 3D-printed - cube, pyramid, cylinder, sphere and torus. The printing process did not affect the stability of the drug. Drug release from the tablets was not dependent on the surface area but instead on surface area to volume ratio, indicating the influence that geometrical shape has on drug release. An erosion-mediated process controlled drug release. This work has demonstrated the potential of 3DP to manufacture tablet shapes of different geometries, many of which would be challenging to manufacture by powder compaction.

Type: Article
Title: Effect of geometry on drug release from 3D printed tablets
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ijpharm.2015.04.069
Publisher version: http://dx.doi.org/10.1016/j.ijpharm.2015.04.069
Language: English
Additional information: © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/1472081
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