Bertrand, J;
De Iorio, M;
Balding, DJ;
(2015)
Integrating dynamic mixed-effect modelling and penalized regression to explore genetic association with pharmacokinetics.
Pharmacogenet Genomics
, 25
(5)
pp. 231-238.
10.1097/FPC.0000000000000127.
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Abstract
In a previous work, we have shown that penalized regression approaches can allow many genetic variants to be incorporated into sophisticated pharmacokinetic (PK) models in a way that is both computationally and statistically efficient. The phenotypes were the individual model parameter estimates, obtained a posteriori of the model fit and known to be sensitive to the study design.
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