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Diabetic foot ulcers in conjunction with lower limb lymphedema: pathophysiology and treatment procedures

Kanapathy, M; Portou, M; Tsui, J; Toby Richards, T; (2015) Diabetic foot ulcers in conjunction with lower limb lymphedema: pathophysiology and treatment procedures. Chronic Wound Care Management and Research , 2015:2 pp. 129-136. 10.2147/CWCMR.S62919. Green open access

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Abstract

Diabetic foot ulcers (DFUs) are complex, chronic, and progressive wounds, and have a significant impact on morbidity, mortality, and quality of life. A particular aspect of DFU that has not been reviewed extensively thus far is its management in conjunction with peripheral limb edema. Peripheral limb edema is a feature of diabetes that has been identified as a significant risk factor for amputation in patients with DFU. Three major etiological factors in development of lymphedema with concurrent DFU are diabetic microangiopathy, failure of autonomic regulation, and recurrent infection. This review outlines the pathophysiology of lymphedema formation in patients with DFU and highlights the cellular and immune components of impaired wound healing in lymphedematous DFU. We then discuss the principles of management of DFU in conjunction with lymphedema.

Type: Article
Title: Diabetic foot ulcers in conjunction with lower limb lymphedema: pathophysiology and treatment procedures
Open access status: An open access version is available from UCL Discovery
DOI: 10.2147/CWCMR.S62919
Publisher version: http://dx.doi.org/10.2147/CWCMR.S62919
Language: English
Additional information: This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php
Keywords: diabetic foot ulcer, lymphedema, chronic wound, wound management
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/1470793
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