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Role of a functional polymorphism in the F2R gene promoter in sarcoidosis

Platé, M; Lawson, PJ; Hill, MR; Marshall, RP; Booth, HL; Kumari, M; Laurent, GJ; ... Chambers, RC; + view all (2015) Role of a functional polymorphism in the F2R gene promoter in sarcoidosis. [Letter]. Respirology , 20 (8) pp. 1285-1287. 10.1111/resp.12608. Green open access

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Abstract

Sarcoidosis is a multisystem granulomatous disease of unknown aetiology characterized by increased inflammation, and results from gene-environment interactions. Proteinase-activated receptor-1 mediates the interplay between coagulation and inflammation. The rs2227744G > A promoter single nucleotide polymorphism has been linked to inflammation, cardiovascular disease and chronic obstructive pulmonary disease exacerbations. Using a case-control study (184 cases with sarcoidosis and 368 controls), we show that the rs2227744A allele significantly associates with protection from sarcoidosis (P = 0.003, OR = 0.68 (0.52-0.88)).

Type: Article
Title: Role of a functional polymorphism in the F2R gene promoter in sarcoidosis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/resp.12608
Publisher version: http://dx.doi.org/10.1111/resp.12608
Language: English
Additional information: This article is published under a Creative Commons Attribution 4.0 International license (CC BY 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0
Keywords: F2R promoter, proteinase-activated receptor-1, sarcoidosis, single nucleotide polymorphism
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1470773
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