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Phase-Tunable Calcium Phosphate Biomaterials Synthesis and Application in Protein Delivery

Lau, CC; Reardon, PJT; Knowles, JC; Tang, J; (2015) Phase-Tunable Calcium Phosphate Biomaterials Synthesis and Application in Protein Delivery. ACS Biomaterials Science & Engineering , 1 (10) pp. 947-954. 10.1021/acsbiomaterials.5b00179. Green open access

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Abstract

Calcium phosphates (CaP) are important biomaterials used in tissue engineering and drug delivery, due to their biocompatibility, low toxicity, and osteoconductivity. However, controlling the phase of CaP, especially tricalcium phosphate (TCP), is very challenging under mild conditions, particularly when using one preparation protocol for all CaP phases. It is also crucial to produce these biomaterials economically and reproducibly. Herein, three of the most commonly employed CaP, including beta-tricalcium phosphate (β-TCP), dicalcium phosphate anhydrous (DCPA), and hydroxyapatite (HA) were, for the first time, successfully synthesized by altering the reaction solvent, using calcium acetate monohydrate as a precursor and a rapid microwave-assisted synthetic method. A variety of CaP particle morphologies were obtained, including elliptical and plate-shaped with different porosities. Compared with conventional heating, CaP biomaterials synthesized using microwave heating showed greater reproducibility, higher yields, and shorter reaction time. By varying the reaction solvents, morphologies and phases of CaP were controlled, leading to an enhanced protein bovine serum albumin (BSA) loading, with a higher BSA absorption observed according to the trend DCPA> β-TCP > HA. Furthermore, the phase, specific surface area, and pore size were shown to play decisive roles in protein desorption with a higher release amount observed according to the trend DCPA > β-TCP > HA. Finally, it is found that larger pores are also beneficial to BSA adsorption.

Type: Article
Title: Phase-Tunable Calcium Phosphate Biomaterials Synthesis and Application in Protein Delivery
Open access status: An open access version is available from UCL Discovery
DOI: 10.1021/acsbiomaterials.5b00179
Publisher version: http://dx.doi.org/10.1021/acsbiomaterials.5b00179
Language: English
Keywords: Protein loading and release, calcium phosphates, phase control, morphology, microwave
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1470763
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