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Learning Enhances Sensory and Multiple Non-sensory Representations in Primary Visual Cortex

Poort, J; Khan, AG; Pachitariu, M; Nemri, A; Orsolic, I; Krupic, J; Bauza, M; ... Hofer, SB; + view all (2015) Learning Enhances Sensory and Multiple Non-sensory Representations in Primary Visual Cortex. Neuron , 86 (6) pp. 1478-1490. 10.1016/j.neuron.2015.05.037. Green open access

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Abstract

We determined how learning modifies neural representations in primary visual cortex (V1) during acquisition of a visually guided behavioral task. We imaged the activity of the same layer 2/3 neuronal populations as mice learned to discriminate two visual patterns while running through a virtual corridor, where one pattern was rewarded. Improvements in behavioral performance were closely associated with increasingly distinguishable population-level representations of task-relevant stimuli, as a result of stabilization of existing and recruitment of new neurons selective for these stimuli. These effects correlated with the appearance of multiple task-dependent signals during learning: those that increased neuronal selectivity across the population when expert animals engaged in the task, and those reflecting anticipation or behavioral choices specifically in neuronal subsets preferring the rewarded stimulus. Therefore, learning engages diverse mechanisms that modify sensory and non-sensory representations in V1 to adjust its processing to task requirements and the behavioral relevance of visual stimuli.

Type: Article
Title: Learning Enhances Sensory and Multiple Non-sensory Representations in Primary Visual Cortex
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuron.2015.05.037
Publisher version: http://dx.doi.org/10.1016/j.neuron.2015.05.037
Language: English
Additional information: This article is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Gatsby Computational Neurosci Unit
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre
URI: https://discovery.ucl.ac.uk/id/eprint/1470411
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