Yu, DG;
Li, XY;
Wang, X;
Yang, JH;
Bligh, SW;
Williams, GR;
(2015)
Nanofibers Fabricated Using Triaxial Electrospinning as Zero Order Drug Delivery Systems.
ACS Applied Materials & Interfaces
, 7
(33)
pp. 18891-18897.
10.1021/acsami.5b06007.
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Abstract
A new strategy for creating functional trilayer nanofibers through triaxial electrospinning is demonstrated. Ethyl cellulose (EC) was used as the filament-forming matrix in the outer, middle, and inner working solutions and was combined with varied contents of the model active ingredient ketoprofen (KET) in the three fluids. Triaxial electrospinning was successfully carried out to generate medicated nanofibers. The resultant nanofibers had diameters of 0.74 ± 0.06 μm, linear morphologies, smooth surfaces, and clear trilayer nanostructures. The KET concentration in each layer gradually increased from the outer to the inner layer. In vitro dissolution tests demonstrated that the nanofibers could provide linear release of KET over 20 h. The protocol reported in this study thus provides a facile approach to creating functional nanofibers with sophisticated structural features.
| Type: | Article |
|---|---|
| Title: | Nanofibers Fabricated Using Triaxial Electrospinning as Zero Order Drug Delivery Systems |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/acsami.5b06007 |
| Publisher version: | http://dx.doi.org/10.1021/acsami.5b06007 |
| Language: | English |
| Additional information: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials & Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see: http://dx.doi.org/10.1021/acsami.5b06007. |
| Keywords: | gradient distribution, medicated nanofibers, triaxial electrospinning, trilayer structure, zero-order controlled release |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1470364 |
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