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Experience-dependent specialization of receptive field surround for selective coding of natural scenes

Pecka, M; Han, Y; Sader, E; Mrsic-Flogel, TD; (2014) Experience-dependent specialization of receptive field surround for selective coding of natural scenes. Neuron , 84 (2) pp. 457-469. 10.1016/j.neuron.2014.09.010. Green open access

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Abstract

At eye opening, neurons in primary visual cortex (V1) are selective for stimulus features, but circuits continue to refine in an experience-dependent manner for some weeks thereafter. How these changes contribute to the coding of visual features embedded in complex natural scenes remains unknown. Here we show that normal visual experience after eye opening is required for V1 neurons to develop a sensitivity for the statistical structure of natural stimuli extending beyond the boundaries of their receptive fields (RFs), which leads to improvements in coding efficiency for full-field natural scenes (increased selectivity and information rate). These improvements are mediated by an experience-dependent increase in the effectiveness of natural surround stimuli to hyperpolarize the membrane potential specifically during RF-stimulus epochs triggering action potentials. We suggest that neural circuits underlying surround modulation are shaped by the statistical structure of visual input, which leads to more selective coding of features in natural scenes.

Type: Article
Title: Experience-dependent specialization of receptive field surround for selective coding of natural scenes
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuron.2014.09.010
Publisher version: http://dx.doi.org/10.1016/j.neuron.2014.09.010
Language: English
Additional information: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Action Potentials, Animals, Animals, Newborn, Mice, Inbred C57BL, Models, Neurological, Nervous System, Neurons, Photic Stimulation, Visual Cortex, Visual Fields, Visual Pathways, Visual Perception
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre
URI: https://discovery.ucl.ac.uk/id/eprint/1470186
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